Skip to main content

You are here

How do genetic variations impact microbial functions (e.g., in biofilm formation, pathogenicity, and drug resistance)?

Topic

Information Flow and Genetics

Framing Question

How do genetic variations impact microbial functions (e.g., in biofilm formation, pathogenicity, and drug resistance)?

Learning Objectives

  • Define the following: point mutation, genetic insertion, genetic deletion, and frameshift mutation.
  • Given a mutation (genetic variation or change in DNA sequence), predict whether or not that change would result in a change of function for the resulting protein (phenotypic change).
  • Explain Griffith’s classic experiment with rough and smooth cells. Describe the relationship between capsule genes and virulence.
  • For a given point mutation, genetic insertion, or genetic deletion, describe a situation that would result in a frameshift mutation and one that would not.
  • For a given point mutation, genetic insertion, or genetic deletion, describe a situation that would result in a non-functioning protein and one that would not.
  • Compare and contrast the potential effects of a given mutation in an open-reading frame to a mutation in a regulatory region.

Courses

Courses