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How does the phenomenon of linkage affect the assortment of alleles during meiosis?

Topic

Transmission - Patterns of Inheritance

Framing Question

How does the phenomenon of linkage affect the assortment of alleles during meiosis?

Learning Objectives

  • Diagram the process of homologous recombination during meiosis and explain how it can lead to new combinations of linked alleles.
  • Explain the role of homologous recombination in ensuring proper segregation of homologs in meiosis I
  • Explain how a specific combination of linked alleles (haplotype) can persist through many generations (linkage disequilibrium).
  • Calculate gene linkage and genetic map distances and interference from the frequencies of progeny with recombinant phenotypes from genetic crosses.
  • Explain how genetic distance is different from physical distance.
  • Calculate the probability of a particular gamete being produced from an individual, provided map distance.
  • Use statistical analysis to determine how well data from a genetic cross or human pedigree analysis fits theoretical predictions including an explanation of the appropriate statistical test.
  • Explain the meaning of a LOD score.

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