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How do different types of mutations affect genes and the corresponding mRNAs and proteins?

Topic

Genetic variation

Framing Question

How do different types of mutations affect genes and the corresponding mRNAs and proteins?

Learning Objectives

  • Describe how duplications, deletions, inversions, and translocations can affect gene function, gene expression, and genetic recombination. Describe the same for transposable elements.
  • Describe how mutations arise and how environmental factors can increase mutation rate.
  • Cite examples of mutations that can be beneficial to organisms.
  • Interpret results from experiments to distinguish between different types of DNA rearrangements.
  • Distinguish between loss of function and gain of function mutations and their potential phenotypic consequences.
  • Predict the most likely effects on protein structure and function of null, reduction-of-function, overexpression, dominant-negative and gain-of-function mutations.
  • Compare the role of both loss and gain of function mutations in the origin of tumors

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