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How can bioinformatics tools be employed to analyze genetic information?

Topic

DNA - Information Storage [GENOMICS]

Framing Question

How can bioinformatics tools be employed to analyze genetic information?

Learning Objectives

  • Calculate the alignment score between two DNA sequences using a provided scoring matrix.
  • Perform a BLASTN search and interpret the results.
  • Explain the BLASTN algorithm for nucleotide sequence information.
  • Interpret the biological significance of an e-value.
  • Annotate a prokaryotic gene (derive a model).
  • Annotate a eukaryotic gene (derive a model).
  • Create and interpret a multiple sequence alignment (e.g., T-COFFEE, MUSCLE, etc.).
  • For a genomic region of interest (e.g., the neighborhood of a particular gene), use a genome browser to view nearby genes, transcription factor binding regions, epigenetic information, etc.
  • Describe Hidden Markov Models and how they can be used to assess motifs.

Courses

Courses