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What factors determine structure?

Topic

Macromolecular Structure Determines Function and Regulation

Framing Question

What factors determine structure?

Learning Objectives

  • Recognize the repeating units in biological macromolecules and be able to discuss the structural impacts of the covalent and non-covalent interactions involved.
  • Discuss the composition, evolutionary change and hence structural diversity of the various types of biological macromolecules found in organisms.
  • Discuss the chemical and physical relationships between composition and structure of macromolecules.
  • Compare and contrast the primary, secondary, tertiary and quaternary structures of proteins and nucleic acids.
  • Use various bioinformatics approaches to analyze macromolecular primary sequence and structure.
  • Compare and contrast the effects of chemical modification of specific amino acids on a three dimensional structure of a protein.
  • Compare and contrast the ways in which a particular macromolecule might take on new functions through evolutionary changes.
  • Use various bioinformatics and computational approaches to compare primary sequences and identify the impact of conservation and/or evolutionary change on the structure and function of macromolecules.
  • Predict the effects of mutations on the activity, structure or stability of a protein and design appropriate experiments to assess the effects of mutations.
  • Propose appropriate chemical or chemical biology approaches to explore the localization and interactions of biological macromolecules.
  • Discuss how mutations of a duplicated gene generate functional diversity.
  • Evaluate chemical and energetic contributions to the appropriate levels of structure of the macromolecule and predict the effects of specific alterations of structure on the dynamic properties of the molecule.

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