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How is macromolecular structure dynamic?

Topic

Macromolecular Structure Determines Function and Regulation

Framing Question

How is macromolecular structure dynamic?

Learning Objectives

  • Discuss the time scales of various conformational effects in biological macromolecules and design appropriate experiments to investigate ligand induced changes in conformation and dynamics.
  • Discuss the structural basis for the dynamic properties of macromolecules and predict the effects of changes in dynamic properties that might result from alteration of primary sequence.
  • Predict whether a sequence is ordered or disordered and discuss potential roles for disordered regions of proteins.
  • Critically discuss the evidence for and against the roles of dynamics in macromolecular function.

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