How is homeostasis controlled?
- Discuss how chemical processes are compartmentalized in the organism, organ and the cell.
- Explain why biochemical pathways proceed through the intermediates that they do (gradual oxidation or reduction) and why pathways share intermediates
- Summarize the different levels of control (including reaction compartmentalization, gene expression, covalent modification of key enzymes, allosteric regulation of key enzymes, substrate availability and proteolytic cleavage) and relate these different levels of control to homeostasis.
- Compare the temporal aspect of different control mechanisms (e.g. how quickly phosphorylation occurs versus changes in gene expression).
- Hypothesize why and how organs evolved with specialized function in metazoans.
- Discuss different models of allosteric regulation.
- Formulate models relating changes in flux through a pathway to other pathways and overall homeostasis.
- Defend why anabolic and catabolic pathways are compartmentalized in the cell.