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How are structure and function related?

Topic

Macromolecular Structure Determines Function and Regulation

Framing Question

How are structure and function related?

Learning Objectives

  • Use mechanistic reasoning to explain how an enzyme or ribozyme catalyzes a particular reaction.
  • Calculate enzymatic rates and compare these rates and relate these rates back to cellular or organismal homeostasis.
  • Discuss various methods that can be used to determine affinity and stoichiometry of a ligand-macromolecule complex and relate the results to both thermodynamic and kinetic data.
  • Critically assess contributions to specificity in a ligand-macromolecule complex and design experiments to both assess contributions to specificity and test hypotheses about ligand specificity in a complex
  • Discuss the basis for various types of enzyme mechanisms.
  • Predict the biological and chemical effects of either mutation or ligand structural change on the affinity of binding and design appropriate experiments to test their predictions.

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