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How are genomes maintained?

Topic

Information storage and flow are dynamic and interactive

Framing Question

How are genomes maintained?

Learning Objectives

  • State how the cell ensures high fidelity DNA replication and identify instances where the cell employs mechanism for damage repair.
  • Explain what a mutation is at the molecular level, how it arises and how it could potentially affect the organism from gene expression to fitness.
  • Relate how the cell cycle and genome maintenance are coordinated and how disruptions in this coordination could affect the organism.
  • List events that result in genomic instability and explain how the cell responds to restore order and stability.
  • Construct relationships between chromosome and cellular structures (e.g. telomere, centromeres and centrosomes) and explain how these structures are responsible for and/or involved in genomic stability.

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